G1540
Sigma
G Protein-Coupled Receptors
| ISBN-10: | 0-8493-3384-9 |
| ISBN-13: | 978-0-8493-3384-2 |
Description
| General description | Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has utilized contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors. |
Properties
| publication info | T. Haga and G. Berstein, ed., CRC Press, 1999, 424 pp., hard cover |
Table Of Contents
| Table of Contents | NOVEL LIGANDS: LIGAND SCREENING SYSTEMS AND ORPHAN RECEPTORS Measurement of Competitive and Allosteric Interactions in Radioligand Binding Studies- Ligand Screening of G Protein-Coupled Receptors in Yeast- Ligand Screening Using Melanophore Cells: Frog Skin to Combinatorial Chemistry- Screening Orphan Receptors for Native Ligands- FUNCTION AND REGULATION: RECEPTOR-G PROTEIN COUPLING AND DESENSITIZATION Reconstitution of Receptor-Promoted Signal Transduction Using Purified Receptor, G Protein, and Effector- Mutagenesis Approaches for Studying Receptor-G Protein Interactions and Receptor Assembly. G Protein-Coupled Receptor Kinases and Desensitization of Receptors- Internalization and Down regulation of G Protein-Coupled Receptors- Use of Electrophysiology to Monitor and Study Receptor Desensitization- 3D STRUCTURE: LARGE-SCALE EXPRESSION AND ELECTRON AND X-RAY CRYSTALLOGRAPHY Expression in Escherichia coli and Large-Scale Purification of a Rat Neurotensin Receptor- Large-Scale Expression of Receptors in Yeasts-H. Reilander, Electron Crystallography of Membrane Proteins- x-ray Crystallography of Membrane Proteins from Detergent Solution: The Structures of a Ligand-Gated Bacterial Membrane Receptor in Two Conformations: a Gallery at Atomic Resolution- x-ray Crystallography of Membrane Proteins: Concepts and Applications of Lipidic Mesophases to Three-Dimensional Membrane Protein Crystallization- |
